Scope and mechanism of the highly stereoselective metal-mediated domino aldol reactions of enolates with aldehydes
نویسندگان
چکیده
A one-pot transformation, which involves the reaction of ketones with aldehydes in the presence of metal halides to furnish tetrahydro-2H-pyran-2,4-diols in a highly diastereoselective manner, is investigated thoroughly by experiments and computations. The reaction was also successfully implemented on a flow micro reactor system.
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